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This experiment reproduced our prior observation that giredestrant elevates the levels of AA-linked phosphatidylcholine [PC(FA20:4)] and PE(FA20:4), and further extends this finding to T47D cells, while also suggesting that a giredestrant-palbociclib combination enhances this effect (Fig

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Indeed, a significantly lower glutathione-S-transferase (GST) enzyme activity and significantly high MDA levels have been shown in the cumulus cells of poor responders compared to high responders (220)